论文部分内容阅读
目的：探讨ＥＢＶ感染对病毒性肝炎的作用及临床意义。方法：用ＥＬＩＳＡ法和ＰＣＲ法分别检测５７０例病毒性肝炎患者血清中ＥＢＶ－ＩｇＭ、ＩｇＧ和ＥＢＶ－ＤＮＡ。结果：①血清中ＥＢＶ现行感染率（ＥＢＶＩｇＭ和ＰＣＲ阳性）在乙型肝炎１３．０７％（２６／１９９），混合型肝炎２２．９５％（１４／６１），高于甲型３．３７％（３／８９），丙型９．９３％（１４／１４１）和戊型肝炎２．５０％（２／８０）（Ｐ＜０．０５，Ｐ＜０．０１）。②在慢性活动性肝炎１６．０６％（３５／２１８），重症肝炎１４．２８％（２／１４），高于急性肝炎４．７６％（８／１６８），慢性迁延性肝炎４．５０％（５／１１１）（Ｐ＜０．０５，Ｐ＜０．０１）。③４例ＥＢＶ感染的病毒性肝炎患者经干扰素治疗后，１例ＨＢＶ－ＤＮＡ转阴（１／４），而无ＥＢＶ感染患者３例治疗后２例转阴。结论：ＥＢＶ感染是病毒性肝炎慢性化、重症化的重要因素，并可能影响干扰素疗效
Objective: To investigate the effect of EBV infection on viral hepatitis and its clinical significance. Methods: Serum EBV-IgM, IgG and EBV-DNA in 570 patients with viral hepatitis were detected by ELISA and PCR respectively. Results: (1) The prevalence of EBV infection (EBV IgG and PCR positive) in serum was 13.07% (26/199) in hepatitis B, 22.95% (14/61) in mixed hepatitis and 3.37% (3/89), 9.93% (14/141) of C and 2.50% (2/80) of hepatitis E (P <0.05, P <0.01). ② In chronic active hepatitis 16.06% (35/218), severe hepatitis 14.28% (2/14), higher than acute hepatitis 4.76% (8/168), chronic persistent hepatitis 4.50% (5/111) (P <0.05, P <0.01). ③ In 4 patients with EBV-infected viral hepatitis, one case of HBV-DNA was negative (1/4) after treatment with interferon, while 3 cases without EBV infection turned negative after 3 cases of treatment. Conclusion: EBV infection is an important factor in the chronic and severe viral hepatitis and may affect the efficacy of interferon