论文部分内容阅读
肾结石形成是尿液成份异常引起理化过程紊乱的结果,但由于缺少区别结晶形成所涉及的各种理化因素(溶解、成核、结晶聚集及结晶生长)的方法,使这一关系难以分析。本文作者研究了7例复发性草酸钙结石患者和10例健康人的尿液对一水草酸钙(COM)的溶解、结晶生长和结晶聚集三个过程的影响。结果:加入尿液后COM结晶的溶解增加,但加入患者尿液后的增加显著低于加入健康人尿液(P<0.01).患者组尿量(2133±485ml/24h)多于对照组(1357±530ml/24h),两组间结晶生长抑制无差异,但聚集抑制有高度显著差异(P<0.001),
The formation of nephrolithiasis is a result of abnormal physical and chemical processes caused by the abnormal urine composition. However, this relationship is difficult to analyze because of the lack of methods to distinguish the various physical and chemical factors involved in crystal formation (dissolution, nucleation, crystal aggregation and crystal growth). The authors investigated the effects of urine on the dissolution, crystal growth and crystal aggregation of calcium oxalate monohydrate in seven patients with recurrent calcium oxalate stones and 10 healthy controls. Results: The dissolution of COM crystals increased with the addition of urine, but the increase of urinary excretion was significantly lower than that of healthy urine (P <0.01). The urinary volume of patients (2133 ± 485ml / 24h) was more than that of the control group 1357 ± 530ml / 24h). There was no difference in the crystal growth inhibition between the two groups, but there was a highly significant difference in aggregation inhibition (P <0.001)