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已知在肝、肾功能障碍时,药物在体内的动态有很大的变化,而在充血性心力衰竭时,即使没有肝、肾功能障碍,也应想到由于循环血流量的降低,药物在体内的动态也会发生改变。作者等曾报告:速尿在充血性心力衰竭时,其在体内的半衰期比正常显著延长,肾脏清除率也降低,这种变化表明与肾血流量降低有关,为了明确这一点,本次试验使用在体内代谢较少且主要从肾脏排泄的氨苄青霉素。试验对象为住院的充血性心力衰竭的患者,并使用洋地黄治疗。男性4名,女性1名,年龄在23～38
It is known that in the liver and renal dysfunction, there is a great change in the dynamics of the drug in the body. In the case of congestive heart failure, even if there is no liver or renal dysfunction, it should be thought that due to the decrease of circulating blood flow, The dynamics will also change. The authors have reported that furosemide in congestive heart failure, its half-life in vivo significantly longer than normal, renal clearance rate also decreased, this change indicates that the decrease of renal blood flow, in order to clarify this point, this test to use Ampicillin which metabolizes less in the body and is mainly excreted from the kidneys. The subjects were hospitalized patients with congestive heart failure and treated with digitalis. 4 males and 1 females, aged from 23 to 38