Ⅲ、Ⅳ期小儿腹部神经母细胞瘤的联合化疗后延期手术

• 作 者: 刘继炎 耿昌平 易军 蒋嘉萍
• 机 构: 南京市儿童医院外科!210008,南京市儿童医院外科!210008,南京市儿童医院外科!210008,南京市儿童医院外科!210008
• 出 处: 临床外科杂志
• 发表日期: 1998年01期
• 关键词: 神经母细胞瘤 联合化疗 二期切除 一期切除 瘤细胞 病理检查 术后复查 移动度 缩小程度 右肩背

本文总结了近5年我科收治的15例Ⅲ、Ⅳ期小儿腹部神经母细胞瘤的治疗，采用CA－EP方案联合化疗后延期手术切除肿瘤，其中一期切除4例，二期切除8例，三期切除1例；放弃二期手术2例；随访6个月～3．5年，死亡3例。作者认为对Ⅲ、Ⅳ期神经母细胞瘤施行联合化疗后延期手术效果满意，结合病理检查结果提出了延期手术的手术指征，联合化疗给药的途径以及术后化疗的时间。

This article summarizes the treatment of 15 cases of pediatric neuroblastoma of stage Ⅲ and Ⅳ in our department in recent 5 years. The patients were treated with CA-EP regimen and postoperative adjuvant chemotherapy. There were 4 cases in one stage and 8 cases in the second stage , Three cases of resection in 1 case; give up two cases of surgery in 2 cases; followed up for 6 months to 3.5 years, 3 died. The authors believe that the delaying surgery is satisfactory for patients with stage Ⅲ and Ⅳ neuroblastoma combined with chemotherapy. Combined with the results of pathological examination, surgical indications for deferred surgery, the route of combined chemotherapy and the time of postoperative chemotherapy are proposed.