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目的探讨脱氢表雄酮(dehydroepiandrosterone,DHEA)联合微刺激促排卵方案在卵巢低反应患者行体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)助孕治疗中的应用价值。方法选择2012年1月至2013年12月在内蒙古医科大学附属医院生殖中心行IVF-ET助孕治疗并诊断为卵巢反应低下的患者,比较行IVF-ET助孕治疗单用微刺激方案(对照组30周期)和DHEA联合微刺激方案(研究组109周期)促排卵的治疗效果及临床结局。结果研究组109个周期中,平均获卵数(2.40±0.72)个,可移植胚胎数(1.29±1.40)个,优质胚胎数(1.22±0.61)个,取消周期20%;对照组30个微刺激方案促排卵周期中,平均获卵数(1.30±0.62)个,可移植胚胎数(0.76±1.30)个,优质胚胎数(0.22±0.47)个,取消周期5.94%。两组比较差异有统计学意义(P<0.05)。研究组DHEA治疗后基础卵泡刺激素明显降低(P<0.05)。结论 DHEA辅助治疗可以提高卵巢低反应患者的卵巢反应性,应用DHEA联合微刺激方案行IVF-ET助孕治疗可以取得一定的临床效果。
Objective To investigate the value of dehydroepiandrosterone (DHEA) in combination with micro-stimulating ovulation induction (IVF-ET) in the treatment of ovarian hyporesponsiveness in patients undergoing IVF-ET. Methods From January 2012 to December 2013, patients underwent IVF-ET assisted treatment at the Reproductive Center of Inner Mongolia Medical University Affiliated Hospital and diagnosed as having low ovarian response were compared with IVF-ET-assisted pregnancy with single micro-stimulation Group 30 cycles) and DHEA combined with micro-stimulation program (study group 109 cycles) ovulation induction and clinical outcomes. Results The average number of oocytes (2.40 ± 0.72), the number of transplanted embryos (1.29 ± 1.40) and the number of high quality embryos (1.22 ± 0.61) in the 109 cycles of the study group were 20% During the ovulation induction cycle, the average number of oocytes retrieved was 1.30 ± 0.62, and the number of transplanted embryos was 0.76 ± 1.30. The number of high quality embryos was 0.22 ± 0.47 and the cancellation cycle was 5.94%. The difference between the two groups was statistically significant (P <0.05). The basal follicle stimulating hormone in study group after DHEA treatment was significantly lower (P <0.05). Conclusions DHEA adjuvant therapy can improve the ovarian response in patients with low ovarian response. The application of DHEA combined with micro-stimulating therapy in IVF-ET can achieve some clinical effects.