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酒精引起胰腺损伤的机制仍尚未阐明。有人认为酒精能使奥迪氏括约肌痉挛而增加了胰管内压力。管内压力的增高使胰小管破裂,导致胰酶的释放和激活,胰腺自体消化和形成炎症。近年来电生理的发展能更直接地研究奥迪氏括约肌的动力学。作者制作了一种设备可同时测定胰胆管的压力和记录奥迪氏括约肌的肌电活动,该方法能测压达数周之久而不妨碍胆汁胰液排入十二指肠。以负鼠为实验动物,在胰腺头部游离出主胰管并
The mechanism of alcohol-induced pancreatic injury has not yet been elucidated. Some people think that alcohol can make the Audi sphincter spasm and increased pancreatic duct pressure. Increased pressure within the pipe rupture of the pancreatic duct, resulting in the release and activation of pancreatic enzymes, pancreatic autologous digestion and the formation of inflammation. In recent years, the development of electrophysiology can more directly study the dynamics of Audi sphincter. The authors created a device that simultaneously measures the pressure of the pancreaticobiliary duct and records the myoelectrical activity of the Oddi’s sphincter, which can be measured for weeks without disturbing the excretion of bile pancreatic juice into the duodenum. Taking the possum as the experimental animal, the pancreatic head is free from the main pancreatic duct