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目前研究认为,肿瘤是由带有受损DNA的细胞连续异常分裂造成的细胞周期疾病。由CDK7、cyclin H、MAT1组成的复合物CAK,在细胞周期中有重要作用并与多种癌性组织相关。CAK可以调节乳腺癌细胞内ER的转录活性,反向调节成神经瘤细胞G1期的生长/分化转换,在子宫内膜癌组织内高表达,其基因的遗传性变型还可能影响肺癌的危险性等等。这种相关性也预示CAK可能成为未来癌症治疗的新靶点。
Current research suggests that tumors are cell cycle diseases caused by the continuous anomalous division of cells with impaired DNA. The complex of CDK7, cyclin H, MAT1, CAK, plays an important role in the cell cycle and is associated with a variety of cancerous tissues. CAK can regulate the transcriptional activity of ER in breast cancer cells and inversely regulate the growth / differentiation of neuroblastoma cells in G1 phase, which is highly expressed in endometrial carcinoma tissues. Genetic variants of CAK may also affect the risk of lung cancer and many more. This correlation also indicates that CAK may be a new target for future cancer treatment.