Experimental Study on Apoptosis Induced by Ursolic Acid Isolated from Asparagusin HL-60 Cells

• 作 者: 黄镜 孙燕 陆士新 苏涛 焦顺昌
• 出 处: Chinese Journal of Integrated Traditional and Western Medici
• 发表日期: 1999年03期
• 关键词: Apoptosis

Objective: To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL 60 cells. Methods: Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay, DNA gel electrophoresis and morphology observation respectively. Results: The IC 50 value of ursolic acid for HL 60 cells was found to be 8.26 μmol/L and 10～50 μmol/L of ursolic acid could induce apoptosis of HL 60 cells exposed to ursolic acid for 1 day. Conclusion: Ursolic acid can markedly inhibit HL 60 cells as well as induction of cells apoptosis.

Objective: To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL 60 cells. Methods: Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay. Results: The IC 50 value of ursolic acid for HL 60 cells was found to be 8.26 μmol / L and 10 ~ 50 μmol / L of ursolic acid could induce apoptosis of HL 60 cells to ursolic acid for 1 day. Conclusion: Ursolic acid can markedly inhibit HL 60 cells as well as induction of cells apoptosis.