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当今抗恶性肿瘤的化疗加重了药物对患者的毒性作用,存在着对人体健康部位的损害比对肿瘤或肿瘤转移有更严重的危险性。 N’-(3-羟丙基)二氨基磷酸内酯(Oxazaphosphorine)类抗癌药(如环磷酰胺、异环磷酰胺和氯乙环磷酰胺等)的毒性不仅由于其烷基化作用,而且还可产生丙烯醛(CH_2=CH-CHO,由肾脏安泄的初级代谢物在尿液中自然产生)。丙烯醛是N’-(3-羟丙基)二氨基磷酸内酯类抗癌药造成泌尿道毒性的主要因素,特别是出血性膀胱炎,已严重到使这些有效药物的治疗使用受到限制。彻底阐明此泌尿道毒性机
Today’s anti-cancer chemotherapy aggravates the toxic effects of drugs on patients, there is a more serious risk of damage to human health than cancer or tumor metastasis. The toxicity of N ’- (3-hydroxypropyl) oxazaphosphorine anticancer drugs such as cyclophosphamide, ifosfamide and cefotaxime not only because of their alkylation, But also produces acrolein (CH 2 ═CH-CHO, a naturally occurring primary metabolite secreted by the kidneys in the urine). Acrolein is a major contributor to urinary tract toxicity caused by N ’- (3-hydroxypropyl) diamino-lactone anticancer drugs, especially hemorrhagic cystitis, which has been so severe that therapeutic use of these effective drugs is limited. Thoroughly elucidate this urinary tract toxicity machine