【摘 要】
：
Identifying data-driven biotypes of major depressive disorder (MDD) has promise for the clarification of diagnostic heterogeneity.However,few studies have focused on white-matter abnormalities for MDD subtyping.This study included 116 patients with MDD an
【机 构】
：
Mental Health Centre, West China Hospital, Sichuan University, Chengdu 610041, China;Huaxi Brain Res
论文部分内容阅读
Identifying data-driven biotypes of major depressive disorder (MDD) has promise for the clarification of diagnostic heterogeneity.However,few studies have focused on white-matter abnormalities for MDD subtyping.This study included 116 patients with MDD and 118 demographically-matched healthy controls assessed by diffusion tensor imaging and neurocognitive evaluation.Hierarchical clustering was applied to the major fiber tracts,in conjunction with tract-based spatial statistics,to reveal white-matter alterations associated with MDD.Clinical and neurocognitive differences were compared between identified subgroups and healthy controls.With fractional anisotropy extracted from 20 fiber tracts,cluster analysis revealed 3 subgroups based on the patterns of abnormalities.Patients in each subgroup versus healthy controls showed a stepwise pattern of white-matter alterations as follows:subgroup 1 (25.9％ of patient sample),widespread white-matter disruption;subgroup 2 (43.1％ of patient sample),intermediate and more localized abnormalities in aspects of the corpus callosum and left cingulate;and subgroup 3 (31.0％ of patient sample),possible mild alterations,but no statistically significant tract disruption after controlling for family-wise error.The neurocognitive impairment in each subgroup accompanied the white-matter alterations:subgroup 1,deficits in sustained attention and delayed memory;subgroup 2,dysfunction in delayed memory;and subgroup 3,no significant deficits.Three subtypes of white-matter abnormality exist in individuals with major depression,those having widespread abnormalities suffering more neurocognitive impairments,which may provide evidence for parsing the heterogeneity of the disorder and help optimize typespecific treatment approaches.
其他文献
Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology.In the present study,we analyzed the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) in
The voltage-gated Na+ channel subtype Nav1.7 is important for pain and itch in rodents and humans.We previously showed that a Navl.7-targeting monoclonal antibody (SVmab) reduces Na+ currents and pain and itch responses in mice.Here,we investigated whethe
Neuronal polarity is involved in multiple developmental stages,including cortical neuron migration,multipolar-to-bipolar transition,axon initiation,apical/basal dendrite differentiation,and spine formation.All of these processes are associated with the cy
Neuroimmune system may be involved in the pathological process of bipolar disorder (BD),but the essential association is not fully understood.Accumulating evidence has shown that BD involves the activation of immune cells and the release of inflammatory s
Immunoglobulin G against myelin oligodendrocyte glycoprotein (MOG-IgG) is detectable in neuromyelitis optica spectrum disorder (NMOSD) without aquaporin4 IgG (AQP4-IgG),but its pathogenicity remains unclear.In this study,we explored the pathogenic mechani
A deficit in spatial memory has been taken as an early predictor of Alzheimer\'s disease (AD) or mild cognitive impairment (MCI).The uncinate fasciculus (UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofron
In this study,the effects of Radio Electric Asymmetric Conveyer (REAC),a non-invasive physical treatment,on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP),were
In this study,the distribution of five Alzheimer\'s disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis.The associations
Huntington\'s disease (HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene.Mutant Huntingtin protein (mHTT) forms abnormal aggregates and intranuclear inclusions in specific neurons,resulting in cell d
Bipolar disorder (BD) is a chronic,recurrent,disabling disease,even when given currently-available pharmacological and psychological treatments.Currently,the etiology and pathogenesis of BD remain unclear.