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目的:调查糖尿病患者合并高甘油三脂血症及高尿酸血症的发病率并探讨其治疗方法及相关作用机制。方法:通过门诊及住院筛查糖尿病合并高甘油三脂血症及高尿酸血症的患者,统计糖尿病合并高甘油三脂血症患者及高尿酸血症患者的发病率;对入选患者按照自愿的原则服用二甲双胍及非洛贝特,在方案实施的终点检测空腹血糖、口服75g葡萄糖后2小时的血糖、血尿酸、血清总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等指标并与方案实施起点进行对比,了解考察指标变化情况。结果:通过调查分析,糖尿病合并高尿酸血症的发病率为25.6%;糖尿病合并高甘油三酯血症及高尿酸血症的患者在所调查的糖尿病人群中的比例为1.34‰;二甲双胍联合非洛贝特治疗后,观察对象不仅上述指标均有明显下降(P<0.05),尤其是血尿酸下降更为明显(P<0.01),均具有统计学意义。结论:二甲双胍联合非洛贝特不仅可以降低糖尿病患者血糖、甘油三酯,还能降低糖尿病患者血尿酸。
Objective: To investigate the incidence of diabetes mellitus complicated with hypertriglyceridemia and hyperuricemia and to explore its treatment and related mechanisms. Methods: The outpatients and inpatients were screened for the incidence of diabetic patients with hypertriglyceridemia and hyperuricemia. The incidences of patients with diabetes mellitus complicated with hypertriglyceridemia and hyperuricemia were calculated. The patients were selected according to voluntary The principle of taking metformin and felbolite, at the end of the program to detect fasting blood glucose, oral glucose 75g 2 hours after oral glucose, serum uric acid, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol Indicators and compared with the starting point for the implementation of the program to understand the changes in the inspection indicators. Results: The incidence of diabetes mellitus with hyperuricemia was 25.6%. The proportion of patients with diabetes mellitus with hypertriglyceridemia and hyperuricemia was 1.34 ‰ in the investigated diabetic population. Metformin combined with non-diabetic patients After treatment with Lobet, not only the above indexes were significantly decreased (P <0.05), especially the decrease of serum uric acid (P <0.01), all of which were statistically significant. Conclusion: Metformin combined with Felofibrate can not only reduce blood glucose and triglycerides in diabetic patients, but also reduce blood uric acid in diabetic patients.