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由于机体对感染的结核分枝杆菌(结核杆菌)的免疫反应不足,致使每年约300万人死于结核病。虽然BCG疫苗使用广泛,但其作为一种预防、治疗有很大局限性。此外,有效治疗要求病人在确诊后至少半年内服用大量联合抗菌药,这在世界上许多地方很难达到,且受限于结核杆菌耐药株的出现。因此促
About 3 million people die from tuberculosis each year due to the body’s lack of immune response to infected Mycobacterium tuberculosis (M. tuberculosis). Although BCG vaccine is widely used, its application as a prevention and treatment has great limitations. In addition, effective treatment requires that patients take a large number of combined antibacterials at least six months after diagnosis, which is difficult to achieve in many parts of the world and is limited by the emergence of M. tuberculosis-resistant strains. So urge