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目的探讨尼莫地平联合抗栓药物治疗短暂性脑缺血发作(TIA)的临床疗效及作用机制。方法选择72例TIA患者,随机分为治疗组和对照组各36例,治疗组采用静脉持续泵入尼莫地平加基础抗栓治疗,对照组采用基础抗栓治疗。结果治疗组总有效率为94.4%,显著高于对照组80.6%(P<0.05)。结论尼莫地平联合基础抗栓治疗TIA可进一步提高疗效。
Objective To investigate the clinical efficacy and mechanism of nimodipine combined with antithrombotic therapy in treating transient ischemic attack (TIA). Methods Seventy-two patients with TIA were randomly divided into treatment group (n = 36) and control group (n = 36). The patients in the treatment group were treated with intravenous infusion of nimodipine plus basic antithrombotic therapy while those in the control group were treated with basic antithrombotic therapy. Results The total effective rate in the treatment group was 94.4%, significantly higher than that in the control group (80.6%, P <0.05). Conclusion Nimodipine combined with basic antithrombotic therapy can further improve the efficacy of TIA.