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目的探讨妇女的初潮年龄及哺乳时间与骨代谢的关系。方法采用统一问卷表方式调查问卷,早晨8:00～10:00取空腹血和第2次晨尿,测定尿钙(Ca)、肌酐(Cr)、血ALP及骨密度。结果初潮年龄在17岁以上者Ca/Cr、ALP值高于初潮年龄<17岁的两组,L2～L4、Wards三角区、股骨上段总骨密度值低于初潮年龄小于15岁组,P<0.05;妇女一生哺乳时间大于2年组骨形成指标血ALP,骨吸收指标尿Ca/Cr高于哺乳时间小于2年组,骨密度值均低于哺乳时间小于2年组。结论初潮晚、哺乳时间长是骨质疏松的高危因素,容易发生骨质疏松。
Objective To investigate the relationship between women’s menarche age and breastfeeding time and bone metabolism. Methods The questionnaires were collected by questionnaire. The fasting blood and second morning urine were collected at 8: 00-10: 00 in the morning. Urinary calcium (Ca), creatinine (Cr), blood ALP and bone mineral density were measured. Results The value of Ca / Cr and ALP in menarche at 17 years old was higher than that in menarche <17 years old, L2 ~ L4, Wards triangle. The total femoral head BMD was lower than that of menarche at 15 years old (P < 0.05. The bone mineral density (ALP) and urinary Ca / Cr of bone resorption index of women whose breast-feeding time was more than 2 years were higher than that of breast-feeding less than 2 years. The BMD values were lower than those of breast-feeding less than 2 years. Conclusion Late menarche, long breast-feeding is a high risk factor of osteoporosis, prone to osteoporosis.