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目的研究观察Ki-67蛋白质在在慢性结肠炎和结肠癌中的表达并探讨其相关的临床意义。方法收集100例患者在结肠镜下取活检的结肠粘膜组织,做免疫组织化学染色及HE染色并作出相应的病理分析。结果通过免疫组织化学染色,Ki-67蛋白质的表达在慢性结肠炎和结肠癌中的比较,在结肠癌中的表达明显增多(P<0.05)。结论在结肠癌Ki-67蛋白质的表达明显增多,其在慢性结肠炎和结肠癌的临床诊断及治疗中可能有一定的临床应用价值。
Objective To investigate the expression of Ki-67 protein in chronic colitis and colon cancer and to explore its clinical significance. Methods Colonic mucosa tissues of 100 patients undergoing colon biopsy were collected for immunohistochemical staining and HE staining and the corresponding pathological analysis was performed. Results By immunohistochemical staining, the expression of Ki-67 protein in chronic colitis and colon cancer was significantly increased in colon cancer (P <0.05). Conclusion The expression of Ki-67 protein in colon cancer is significantly increased, which may have some clinical value in the clinical diagnosis and treatment of chronic colitis and colon cancer.