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目的 探讨μ阿片受体激动剂对慢性缺氧模型呼吸功能的影响。方法 正常大鼠侧脑室注射羟甲芬太尼（Ｏｈｍｅｆｅｎｔａｎｙｌ，ＯＭＦ）后，观察记录呼吸频率（ＲＲ）；侧脑室微量注射阿片受体拮抗剂纳洛酮（ＮＬＸ）、ＯＭＦ，测定ＲＲ、潮气量（ＶＴ）及血气指标，并对每分通气量（ＭＶ）与ＰａＣＯ２作线性回归分析。结果 正常大鼠侧脑室注射ＯＭＦ后，ＲＲ显著下降（Ｐ＜０．０５）。慢性缺氧模型侧脑室注射ＯＭＦ后显著降低ＲＲ、ＶＴ以及中枢对ＣＯ２的敏感性（Ｐ＜０．０１）。电性缺氧模型侧脑室注射ＮＬＸ后，ＲＲ显著增高（Ｐ＜０．０５），并可增强中枢对ＣＯ２的敏感性。结论 μ阿片受体激动剂通过与中枢阿片受体结合降低ＲＲ、ＶＴ等呼吸指标以及中枢对ＣＯ２的敏感性，从而显著影响慢性缺氧模型的呼吸功能。
Objective To investigate the effect of μ opioid receptor agonist on respiratory function in chronic hypoxia model. Methods The normal rats were injected oxymethamine (OMF) into the lateral ventricle and the respiratory rate (RR) was recorded. The opioid receptor antagonist naloxone (OMX) and OMF were injected into the lateral ventricle to measure the RR and tidal volume (VT) and blood gas index, and the linear regression analysis of per minute ventilation (MV) and PaCO2. Results After normal rats were injected OMF into the lateral ventricle, RR decreased significantly (P <0.05). Chronic hypoxia model significantly reduced the sensitivity of RR, VT and central CO2 to OMF after intracerebroventricular injection of OMF (P <0.01). In the anoxic hypoxic model, the RR of NLX increased significantly (P <0.05) and increased the central CO2 sensitivity. Conclusion μ opioid receptor agonist can decrease the respiratory index such as RR and VT and the central sensitivity to CO2 by binding with central opioid receptor, thus significantly affect the respiratory function of chronic hypoxia model.