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目的探讨TLR7(Toll-Like Receptor 7,)基因多态性与丙型肝炎病毒(Hepatitis C Virus,HCV)感染转归的关系。方法运用Taq Man-MGB荧光探针法检测1 146例健康对照者,299例HCV自限清除者以及410例HCV持续感染者中TLR7多态性位点,比较不同位点基因型与HCV感染转归的关系。结果在女性人群中,rs179009位点突变基因型GG可增加HCV感染的风险(OR=2.40,95%CI:1.09~5.27),rs3853839位点突变基因型CC降低HCV感染慢性化的风险(OR=0.31,95%CI:0.10~0.94);单倍型AC和GG可显著降低HCV感染慢性化的风险。结论 TLR7基因多态性可能与女性丙型肝炎易感性及慢性化有关。
Objective To investigate the relationship between the polymorphism of Toll-Like Receptor 7 (TLR7) and the prognosis of Hepatitis C Virus (HCV) infection. Methods The TLR7 polymorphism loci in 1 146 healthy controls, 299 HCV self-limited eradicators and 410 HCV co-infected individuals were detected by Taq Man-MGB fluorescent probe. The relationship. Results In the female population, genotype GG at rs179009 increased the risk of HCV infection (OR = 2.40, 95% CI: 1.09-5.27). The rs3853839 site mutation genotype CC reduced the risk of chronic HCV infection (OR = 0.31, 95% CI: 0.10 ~ 0.94). Haplotype AC and GG significantly reduced the risk of chronic HCV infection. Conclusion TLR7 gene polymorphism may be related to the susceptibility and chronicity of hepatitis C in women.