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急性实验中，间隔５ｍｉｎ反复注射烟碱０．５，１．０，１．０，２．０，２．０ｍｇ／ｋｇｉｐ，３０ｍｉｎ后大鼠大脑皮层及海马中肌醇含量升高，但纹状体中肌醇含量无显著变化；相同条件下，氯化锂１０ｍｍｏｌ／ｋｇｉｐ３０ｍｉｎ后大脑皮层和海马中肌醇含量显著降低；慢性实验中，烟碱２．０－１０．０ｍｇ／ｋｇｓｃｂｉｄ１４ｄ后，大鼠大脑皮层中肌醇含量显著增高；烟碱２．６９－１１．５３ｍｇ／ｋｇ／ｄｐｏ６４ｄ后，大鼠大脑皮层中肌醇含量也显著增高。表明烟碱的作用不同于氯化锂，反复给予烟碱可使大鼠大脑皮层中肌醇含量增加。
In acute experiment, nicotine 0.5, 1.0, 1.0, 2.0 and 2.0 mg / kg ip were injected repeatedly 5 min intervals, and the content of inositol in cerebral cortex and hippocampus of rats increased after 30 min, Inositol content in the body had no significant change; under the same conditions, the inositol content in the cerebral cortex and hippocampus of 10mmol / kgip30min after lithium chloride was significantly reduced; in the chronic experiment, after the nicotine 2.0-10.0mg / kgscbid for 14d, Inositol content of cerebral cortex was significantly increased; nicotine 2.69-11.53mg / kg / dpo64d after in rat cerebral cortex inositol content was significantly higher. The effect of nicotine is different from that of lithium chloride. Repeated administration of nicotine increases the inositol content in the cerebral cortex of rats.