Incorporation of azide sugar analogue decreases tumorigenic potential of breast cancer cells by redu

• 作 者: DUAN XinRui CAI Li LEE Lim Andrew CHEN HeXin WANG Qian
• 机 构: Department of Chemistry and Biochemistry,University of South Carolina,Columbia 29208,USA,Division of
• 出 处: Science China(Chemistry)
• 发表日期: 2013年03期
• 关键词: triple analogue sugar azide progesterone proportion attributed estrogen metastas

The azido sugar,GalNAz,was successfully used for imaging and perturbing protein glycosylation in triple-negative breast cancer cell line,MDA-MB-231.After the incorporation of GalNAz in the triple-negative breast cancer cell line,the tumorigenicity of these cells was decreased.Results from gene analysis and drug treatment suggest that the tumorigenicity decrease may be attributed to the reduction of cancer stem cell population.Possible mechanisms of GalNAz induced cancer stem cells(CSCs) proportion change are discussed.