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人蛋白C(PC)是一种维生素K依赖性糖蛋白,经活化后成为止血调节系统的一种重要中心酶。PC在血浆中循环,并在内皮细胞表面被凝血酶-血栓调节蛋白(T-TM)复合物所激活。激活后的PC(APC)通过灭活因子Ⅴ_a和Ⅶ_a,具有抗凝血活性,并能通过灭活纤溶酶原话化抑制剂(PAI-1),而具有前纤维蛋白溶酶的活性。蛋白C的这两种活性作用,能明显地控制止血机制,限制血凝块的过量形成。遗传性纯含子缺乏PC的人,在出生时即会发生严重的爆发性紫癜,如不及时用PC替代治疗,婴儿可在产后数日内死亡。作者比较和研究了基因重组蛋白C(r-PC)与天然血源蛋白C(n-PC)的结构及功
Human protein C (PC) is a vitamin K-dependent glycoprotein that, upon activation, becomes an important central enzyme in the hemostatic regulatory system. The PC circulates in the plasma and is activated on the endothelial cell surface by the thrombin-thrombomodulin (T-TM) complex. Activated PC (APC) has anticoagulant activity by inactivating factor Ⅴ_a and Ⅶ_a, and possesses pre-plasmin activity by inactivating plasminogen activator (PAI-1). These two activities of protein C, can significantly control the hemostatic mechanism, limiting the excessive formation of blood clots. People with hereditary pure IL-deficient PC will develop severe fulminant purpura at birth and may die within a few days after giving birth if left untreated with PC. The authors compared and studied the structure and function of recombinant protein C (r-PC) and native blood protein C (n-PC)