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20例患者于开始庆大霉素治疗24小时期间,在庆大霉素剂最静滴完毕后,于0.5和4小时抽取血祥,药物动力学参数值的计算系采用单室模型处理,剂量调整至庆大霉素达峰浓度为4～8μg/ml及谷浓度为0.5～1.5μg/ml.在研究中,10例接受庆大霉素的负荷剂量为1.1～2.6μg/kg。维持剂量为2.1～6.7mg/kg/d(平均=3.8mg/kg/d)。10例给予庆大霉素80
Blood samples were collected at 0.5 and 4 hours after the gentamicin was most intravenously administered in 20 patients during the first 24 hours of gentamicin treatment. The pharmacokinetic parameters were calculated using a single-compartment model. The dose Adjusted to a peak gentamicin concentration of 4 ~ 8μg / ml and trough concentrations of 0.5 ~ 1.5μg / ml in the study, 10 cases received gentamicin loading dose of 1.1 ~ 2.6μg / kg. The maintenance dose was 2.1 to 6.7 mg / kg / d (mean = 3.8 mg / kg / d). 10 cases given gentamicin 80