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作者于1976年11月至1977年3月观察了6例各类白血病患者,其中慢性淋巴细胞性白血病3例,粒细胞性白血病3例,在粒细胞性白血病中,急性原粒细胞性白血病、慢性粒细胞性白血病和转化的慢性粒细胞白血病各1例。全部患者均有高粘滞度综合征(Hyperviscosity syndrome)的相同症状,包括极度嗜睡、步态不稳、视力障碍和昏迷等。2例还有双侧视网膜出血,但无严重的血小板减少症或凝血异常;3例有听力下降。 6例患者均以连续式血细胞分离器进行白细胞去除(Leucapheresis),同时使用肝素抗凝和葡聚糖150以促进白细胞分离。经上述处理后,3例患者的神经症状迅速完全好转;1例部分好转;1例于进行白细
The author observed from November 1976 to March 1977 6 cases of various types of leukemia patients, including 3 cases of chronic lymphocytic leukemia, myelogenous leukemia in 3 cases, in myeloid leukemia, acute myeloid leukemia, One case of chronic myeloid leukemia and one case of transformed chronic myeloid leukemia. All patients had the same symptoms of Hyperviscosity Syndrome, including extreme lethargy, unstable gait, visual impairment and coma. There were 2 cases of bilateral retinal hemorrhage, but no severe thrombocytopenia or coagulation abnormalities; 3 cases of hearing loss. All 6 patients underwent leucapheresis with a continuous hemacytometer, while heparin anticoagulation and dextran 150 were used to promote leukapheresis. After the above-mentioned treatment, the neurological symptoms of 3 patients were completely and rapidly improved; 1 patient partially improved; 1 patient was white