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AIM:To evaluate the efficacy of Stretta procedure with gastroesophageal reflux disease(GERD)based on symptom control,medication changes and oesophagitis grade.METHODS:Ninety patients with a history of GERD underwent Stretta procedure from June 2007 to March 2010.All patients with GERD diagnosed by the pres-ence of endoscopically evidenced oesophagitis or abnormal esophageal pH testing.We evaluated GERD-health-related quality of life,satisfaction,medication use and endoscopy at baseline,6,12 mo after treatment.Complications of the procedure were analyzed.RESULTS:We found that patients experienced significant changes in symptoms of GERD after Stretta proce-dure.The onset of GERD symptom relief was less than 2 mo(70.0%)or 2 to 6 mo(16.7%).The mean GERD-HRQL score was 25.6(baseline),7.3(6 mo,P<0.01),and 8.1(12 mo,P<0.01).The mean heartburn scorewas 3.3(baseline),and 1.2(12 mo,P<0.05).The percentage of patients with satisfactory GERD control improved from 31.1%at baseline to 86.7%after treat-ment,and patient satisfaction improved from 1.4 at baseline to 4.0 at 12 mo(P<0.01).Medication usage decreased significantly from 100%of patients on pro-ton pump inhibitors therapy at baseline to 76.7%of patients showing elimination of medications or only as needed use of antacids/H2-RA at 12 mo.An improvement in endoscopic grade of oesophagitis was seen in 33 of the 41 patients.All patients had either no erosions or only mild erosive disease(grade A)at 6 mo.CONCLUSION:The experience with Stretta procedure confirms that it is well tolerated,safe,effective and durable in the treatment of GERD.The Stretta procedure provides the drug-refractory patients with a new mini-mally invasive method.
AIM: To evaluate the efficacy of Stretta procedure with gastroesophageal reflux disease (GERD) based on symptom control, medication changes and oesophagitis grade. METHODS: Ninety patients with a history of GERD underwent Stretta procedure from June 2007 to March 2010. All patients with GERD diagnosed by the pres-ence of endoscopically evidenced oesophagitis or abnormal esophageal pH testing. We evaluated GERD-health-related quality of life, satisfaction, medication use and endoscopy at baseline, 6,12 mo after treatment. Complications of the procedure were analyzed. RESULTS: We found that patient who had significant changes in symptoms of symptoms of GERD after Stretta proce-dure.The onset of GERD symptom relief was less than 2 mo (70.0%) or 2 to 6 mo (16.7%). The mean GERD-HRQL score was 25.6 (baseline), 7.3 (6 mo, P <0.01), and 8.1 (12 mo, P <0.01) .The mean heartburn scorewas 3.3 (baseline), and 1.2 patients with satisfactory GERD control improved from 31.1% at baseline to 86.7% after trea t-ment, and patient satisfaction improved significantly from 1.4 at baseline to 4.0 at 12 mo (P <0.01). Medication usage decreased significantly from 100% of patients on pro-ton pump inhibitors therapy at baseline to 76.7% of patients showing elimination of medications or only as needed use of antacids / H2-RA at 12 months. Any improvement in endoscopic grade of oesophagitis was seen in 33 of the 41 patients. All patients had either no erosions or only mild erosive disease (grade A) at 6 months. CONCLUSION: The experience with Stretta procedure confirms that it is well tolerated, safe, effective and durable in the treatment of GERD. Stretta procedure provides the drug-refractory patients with a new mini-mally invasive method.