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目的：对比不同剂量的地佐辛复合丙泊酚在抑制妇科门诊老年患者无痛诊刮围术期应激反应的临床效果,探讨其在门诊当日离院老年女性患者应用的可行性以及安全性。方法选择妇科门诊女性(≥55岁)拟行无痛诊刮手术的患者300例,ASA分级Ⅰ-Ⅱ级,随机分为地佐辛0.1mg/kg复合丙泊酚组(A组)(n=100)、地佐辛0.15mg/kg复合丙泊酚组(B组)(n=100)和丙泊酚组(C组)(n=100)三组,术前10min A组静脉推注地佐辛0.1mg/kg,术中丙泊酚持续镇静；术前10min B组静推注地佐辛0.15mg/kg,术中丙泊酚持续镇静；术前10minC组静脉推注生理盐水10mL,术中丙泊酚持续镇静。观察并记录三组不同时间点的各项应激反应指标,对比三组不同用药方式在抑制围术期应激反应的临床效果以及不良反应发生率。结果三组在抑制围术期应激反应方面的临床效果有明显统计学差异(<0.01)：A组和B组在呼吸循环系统方面的稳定性明显优于C组,对血清皮质醇的升高程度也明显低于C组,但是不良反应发生率方面A组(5%)明显低于B组(18%)和C组(42%),(<0.01)。结论地佐辛复合丙泊酚用于抑制妇科当日离院老年患者无痛诊刮术围术期应激反应临床效果比较满意,围术期呼吸循环系统相对比较平稳,但是0.1mg/kg的地佐辛不良反应发生率更低。“,”Obiective To discuss the feasibility and evaluate the effect and safety of different doses of dezocine with Propofol in alleviating the stress response during perioperative period from painless diagnostic curettage for senile patient leaving the hospital the same day . Methods 300 ASAⅠorⅡelderly patients (≥55 years) undergoing painless diagnostic curettage were divided into three groups randomly. Ten minutes before the operation, group A was given dezocine intravenously at the dose of 0.1mg/kg(n=100), and group B was given dezocine intravenously at the dose of 0.15mg/kg(n=100), then group C saline instead at the dose of 10mL (n=100). Propofol was used for sedation maintenance in all groups during the operation. Stress response and untoward effects after the painless diagnostic curettage were observed and recorded.Results There was significant difference between three groups in lessening painless diagnostic curettage induced stress response( <0.01). Group A and group B showed remarkably better control of the stability of the cardiovascular system than group C as well as the increase of serum cortisol. The incidence of total untoward effects was profoundly low in group A(5%) compared to group B(18%) and group C(42%) ( <0.01). Conclusion The effect of intravenous injection of dezocine in decreasing the stress response from painless diagnostic curettage turned out to be satisfactory, and dezocine intravenously at the dose of 0.1mg/kg lowered the incidence of total untoward effects.