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药物的溶解度直接影响药物在体内的吸收和生物利用度,在中药中存在很多药理活性强但溶解性差的成分,如葛根素、喜树碱、鱼腥草素、二氢槲皮素等,需设法增加其溶解度以满足制剂生产和临床用药的需求。近年来,分子包合、固体分散体及微乳等新技术,取得了较好研究成果。但上述方法均存在需添加辅料、借助特殊工艺或设备、适用性有限、带来新的安全隐患等共性问题,制约了其在中药领域的应用[1]。比较而言,中药汤剂作为目前临床最常用的一种剂
The solubility of the drug directly affects the absorption and bioavailability of the drug in the body. There are many components in traditional Chinese medicine with strong pharmacological activity but poor solubility, such as puerarin, camptothecin, houttuyfonate, dihydroquercetin, etc. Try to increase its solubility to meet the demand for formulation production and clinical medication. In recent years, new technologies such as molecular inclusions, solid dispersions, and microemulsions have achieved good results. However, the above methods all have common problems such as the need to add auxiliary materials, the use of special processes or equipment, limited applicability, and new security risks, which restrict their application in the field of traditional Chinese medicine [1]. In comparison, traditional Chinese medicine decoction is the most commonly used agent in clinical practice.