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目的探讨稳心颗粒联合曲美他嗪治疗不稳定型心绞痛的临床疗效。方法选取2015年9月—2016年9月灵寿县医院内科门诊及住院部收治的不稳定型心绞痛患者110例,采用随机数字表法分为对照组和观察组,各55例。两组患者均给予硝酸酯类、抗血小板药物、钙离子阻滞剂及血管紧张素转换酶抑制剂等药物常规基础治疗。对照组患者单纯给予曲美他嗪片治疗,观察组患者在对照组基础上给予稳心颗粒治疗。治疗2周后比较两组患者的临床疗效及治疗前后心绞痛发作频率、心绞痛发作持续时间,并观察患者不良反应发生情况。结果观察组患者的临床疗效优于对照组(P<0.05)。治疗前,两组患者心绞痛发作情况比较,差异无统计学意义(P>0.05);治疗后观察组患者的心绞痛发作情况显著改善,且改善情况优于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论稳心颗粒联合曲美他嗪片治疗不稳定型心绞痛的临床疗效确切,可有效改善患者临床症状,且安全性高。
Objective To investigate the clinical effect of Wenxin Granule combined with trimetazidine in the treatment of unstable angina pectoris. Methods A total of 110 patients with unstable angina pectoris admitted from September 2015 to September 2016 in Lingshou County Hospital were randomly divided into control group and observation group with 55 cases in each group. Two groups of patients were given nitrates, antiplatelet drugs, calcium blockers and angiotensin-converting enzyme inhibitors and other drugs routine basic treatment. Patients in the control group were treated with trimetazidine alone, while patients in the observation group were given Wenxin Granules on the basis of the control group. After 2 weeks of treatment, the clinical curative effect, the frequency of angina pectoris and the duration of angina pectoris before and after treatment were compared between two groups, and the incidence of adverse reactions was observed. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in angina pectoris between the two groups (P> 0.05). After the treatment, angina pectoris in the observation group was significantly improved and the improvement was better than that in the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Wenxin granule combined with trimetazidine tablets in the treatment of unstable angina pectoris has definite curative effect, which can effectively improve the clinical symptoms and is safe.