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血栓性疾病和动脉硬化与血液凝固有关。目前认为低脂肪食物与降血脂药物可以降低血胆固醇,并能够预防心肌梗塞发作,但预防心肌梗塞再发的效果不明显。另一方面,关于抗血小板聚集药物阿司匹林等预防血栓形成、防止心肌梗塞发作也做了大量研究,但都未取得成功。一般认为血栓形成与血管的炎症、高脂血状态下的血小板聚集亢进及粘附力增加,以及凝血亢进有关。近年来人们开始注意到动脉壁和血小板之间花生四烯酸代谢产物前列腺素与血栓形成有密切相关。已知动脉壁内皮细胞和血小板中含有花生四烯酸(AA),在磷脂酶A_2作用下被游离,进一步在环氧酶作用下分解,于血小板中产生血栓素A_2(TxA_2),动
Thrombotic diseases and atherosclerosis are associated with blood clotting. Now that low-fat foods and lipid-lowering drugs can lower blood cholesterol, and can prevent the onset of myocardial infarction, but the effect of preventing recurrence of myocardial infarction is not obvious. On the other hand, a great deal of research has been done on the prevention of thrombosis, such as anti-platelet aggregation drug aspirin, to prevent the onset of myocardial infarction, but none has been successful. Generally believed that thrombosis and vascular inflammation, hyperlipidemia in platelet aggregation and increased adhesion, and hyperthyroidism related. In recent years, people began to notice that there is a close correlation between prostaglandin, an arachidonic acid metabolite, between the arterial wall and platelets and thrombosis. Arterial endothelial cells and platelets are known to contain arachidonic acid (AA), which is liberated by phospholipase A2 and further decomposed by cyclooxygenase to produce thromboxane A2 (TxA2) in platelets.