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目的 探讨谷氨酸单钠 (MSG)对大鼠胃窦部生长抑素 m RNA表达的影响。方法 采用原位杂交技术检测胃窦部生长抑素 m RNA的表达并用计算机图象分析系统进行定量分析。结果 谷氨酸单钠可使胃窦部生长抑素 m RNA表达增强 ,以 5 2天 (青春期 )最为明显 ,12 0天 (成年期 )次之 ,11天 (新生期 )最弱 ,经统计 ,差异具有显著性 (P<0 .0 1)。结论 谷氨酸单钠可使胃窦部 D细胞生长抑素 m RNA表达增强 ,这可能是 MSG导致神经内分泌紊乱的机制之一。
Objective To investigate the effects of monosodium glutamate (MSG) on the expression of somatostatin mRNA in gastric antrum of rats. Methods The expression of somatostatin m RNA in gastric antrum was detected by in situ hybridization and quantified by computer image analysis system. Results Monosodium glutamate increased the expression of somatostatin m RNA in gastric antrum, which was the most obvious in 52 days (adolescence), the weakest was in 120 days (adult) and the weakest in 11 days (in neonatal) , The difference was significant (P <0. 01). Conclusion Monosodium glutamate increased the expression of somatostatin mRNA in D-cell of gastric antrum, which may be one of the mechanisms of MSG leading to neuroendocrine disorders.