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目的探讨单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)在子宫腺肌病发病中的作用。方法采用免疫组化法和实时荧光定量PCR法检测36例子宫腺肌病患者在位内膜、异位病灶组织中的MCP-1含量,并与相应对照组进行比较。结果腺肌病患者在位内膜和异位病灶组织MCP-1含量均高于相应正常对照组(P<0.05);异位病灶组织中MCP-1含量高于在位内膜(P<0.05),且两者具有相关性(r=0.87,P<0.01)。结论 MCP-1可能参与了子宫腺肌病的发病过程,但具体分子机制尚需进一步研究。
Objective To investigate the role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of adenomyosis. Methods The levels of MCP-1 in eutopic and ectopic endometriosis of 36 cases of adenomyosis were detected by immunohistochemistry and real-time fluorescence quantitative PCR, and compared with the corresponding control group. Results The levels of MCP-1 in eutopic and ectopic lesions of adenomyosis patients were significantly higher than those of corresponding normal controls (P <0.05). The contents of MCP-1 in ectopic lesions were higher than that of eutopic endometrium (P <0.05) ), And the correlation between them (r = 0.87, P <0.01). Conclusion MCP-1 may be involved in the pathogenesis of adenomyosis, but the specific molecular mechanism needs further study.