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目的探讨SOD水平对急性心肌梗死(AMI)血运重建患者远期心室重构的相关性。方法符合纳入标准的心肌梗死血运重建患者67(男60,女7)例,年龄为(58±11)岁,AMI的病程(9.1±2.5)h,收集患者临床基线资料、采集入院24 h内空腹静脉血检测血清超氧化物歧化酶(SOD)、超敏C反应蛋白(hs-CRP)及相关生化指标。随访1年后,按左室舒张末期内径(LVEDD)是否增大分为心脏扩大组(男性LVEDD>55 mm,女性LVEDD>50 mm)和心脏未扩大组。结果心脏扩大组SOD水平显著低于心脏未扩大组(P<0.01);心脏扩大组hs-CRP水平显著高于心脏未扩大组(P<0.01);利用二元Logistic回归模型建立数值间线性关系,得出AMI患者SOD表达水平与LVEDD呈负相关(B=-0.049,P<0.05)。结论 SOD水平与AMI血运重建患者心室重构有相关性。
Objective To investigate the correlation between SOD level and long-term ventricular remodeling in patients with acute myocardial infarction (AMI) revascularization. Methods A total of 67 patients (60 males and 7 females) with myocardial infarction were enrolled in this study. The mean age was (58 ± 11) years. The course of AMI was 9.1 ± 2.5 h. The clinical baseline data of patients were collected and collected for 24 h Serum levels of superoxide dismutase (SOD), high-sensitivity C-reactive protein (hs-CRP) and related biochemical parameters were determined by fasting venous blood. One year after follow-up, the subjects were divided into two groups: enlarged heart group (LVEDD> 55 mm in male group, female LVEDD> 50 mm group) and non-enlarged heart group according to whether left ventricular end diastolic diameter (LVEDD) increased. Results The level of SOD in heart enlargement group was significantly lower than that in non-enlargement group (P <0.01). The level of hs-CRP in heart enlargement group was significantly higher than that in non-enlargement group (P <0.01). Logistic regression model was used to establish the linear relationship It was concluded that the level of SOD in patients with AMI was negatively correlated with LVEDD (B = -0.049, P <0.05). Conclusion The level of SOD is correlated with ventricular remodeling in AMI revascularization.