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目的观察胺碘酮联合小剂量美托洛尔治疗快速心律失常的疗效及安全性。方法将60例快速心律失常患者随机分成治疗组和对照组,分别静脉用胺碘酮与美托洛尔和胺碘酮,比较两组患者用药后疗效和不良反应。结果治疗组窦性心律转复率及有效率(93.8%,96.9%)高于对照组(71.4%,82.1%)(P<0.05),起效时间(h)短于对照组[(0.6±0.2)vs(8.1±0.2),P<0.05];治疗组治疗后血压显著下降(P<0.05);两组患者治疗后心率均下降(P<0.05);两组均未出现严重不良反应。结论胺碘酮联合小剂量美托洛尔治疗快速心律失常安全且有效。
Objective To observe the efficacy and safety of amiodarone in combination with low dose metoprolol in the treatment of tachyarrhythmia. Methods Sixty patients with tachyarrhythmia were randomly divided into treatment group and control group. Amiodarone, metoprolol and amiodarone were given intravenously. The curative effect and adverse reactions of the two groups were compared. Results The sinus rhythm recovery rate and effective rate (93.8%, 96.9%) in the treatment group were significantly higher than those in the control group (71.4%, 82.1%, P <0.05) 0.2) vs (8.1 ± 0.2), P <0.05]. The blood pressure of the treatment group decreased significantly after treatment (P <0.05). The heart rate of both groups decreased after treatment (P <0.05). No serious adverse reactions occurred in both groups. Conclusions Amiodarone and low-dose metoprolol are safe and effective in the treatment of tachyarrhythmias.