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目的回顾性比较丙泊酚与地西泮治疗癫持续状态的疗效。方法选择我院住院近3a的成人癫持续状态患者30例。对照组(15例)选用地西泮静脉推注(10～20mg),注射完毕后给予地西泮50mg加入0.9%氯化钠500mL缓慢静滴维持,24h总量不超过120mg;治疗组(15例)选用丙泊酚1.5～2.5mg/kg静滴,静脉微泵维持剂量1～4mg/(kg.h)。结果 2组抽搐终止发作和控制时间比较差异有统计学意义(P<0.05)。结论丙泊酚组在终止癫发作和起效时间均优于地西泮组。
Objective To retrospectively compare the efficacy of propofol and diazepam in the treatment of persistent epilepticus. Methods Thirty patients with persistent epilepsy in our hospital for nearly 3 years were selected. The control group (15 cases) received intravenous injection of diazepam (10-20 mg). After the injection, 50 mg of diazepam was added to 500 ml of 0.9% sodium chloride for slow intravenous infusion and the total volume was less than 120 mg. Example) Propofol 1.5 ~ 2.5mg / kg infusion, intravenous micro-pump maintenance dose of 1 ~ 4mg / (kg.h). Results The termination of seizure and control time in the two groups were statistically significant (P <0.05). Conclusion Propofol group is better than diazepam group in the termination of epileptic seizures and onset of onset.