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作者报道用 IgG 治疗2例患有自发性因子Ⅷ抑制物的患者。例1:女性,64岁,因严重出血就诊。检测因子Ⅷ小于1%,因子Ⅷ抑制物达141 Bethesda U。经输全血和活性凝血酶原复合浓缩制剂,急性出血控制。由于再次出血,开始采用血浆除去法,但抑制物水平只降至28 Bethesda U,仍继续出血。每天静脉注入 IgG(Sandoglobulin)0.5g/kg 体重,共用8天。第2天因子Ⅷ:C 即增加到3%,2周后达到
The authors report 2 patients with spontaneous factor VIII inhibitors treated with IgG. Example 1: Female, 64 years old, due to severe bleeding. Factor VIII less than 1% and factor VIII inhibitor 141 Bethesda U. Transfusion of whole blood and active prothrombin compound concentrated preparations, acute bleeding control. Due to the rebleeding, plasma removal was started, but the inhibitor level dropped to only 28 Bethesda U and continued to bleed. Intravenous injection of IgG (Sandoglobulin) 0.5g / kg body weight, shared for 8 days. Day 2 Factor VIII: C increased to 3%, reached after 2 weeks