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目的:通过观察活血通络汤治疗激素性股骨头缺血性坏死(SANFH)的空骨陷窝率及病理形态学观察,为通络补肾法防治SANFH提供理论依据。方法:选取96只日本大耳兔分为两组,正常组24只,造模组72只,利用贺氏造模法制造SANFH模型,造模组随机分组4组(高、中、低剂量,模型组),共5组。治疗组分别灌服不同剂量活血通络汤混悬液,模型组、正常组灌服蒸馏水。分别在给药的第6周和第8周,每组随机抽取8只兔子进行血浆VEGF、AKP定量分析与检测。结果:给药后第6、8周,与正常组比较,股骨头空骨陷窝率明显升高(P<0.01)。与模型组比较,活血通络汤组股骨头空骨陷窝率降低(P<0.05);高、中、低剂量组间比较差异显著(P<0.05)。结论:活血通络汤能够显著降低家兔股骨头异常升高的空骨陷窝率,从而有效地防治早中期的家兔股骨头坏死,疗效与剂量、时间呈正相关。
OBJECTIVE: To observe the empty lacunae rate and histopathological observation of Huanxuetongluo Decoction for steroid-induced avascular necrosis of the femoral head (SANFH), and to provide a theoretical basis for the prevention and treatment of SANFH by Tonifying the Kidney and Tonifying the Kidney. Methods: Ninety-six Japanese big-eared rabbits were divided into two groups: normal group (24 rats) and model group (72 rats). SANFH model was made by Hayes modeling and the model group was randomly divided into 4 groups (high, medium and low dose, Model group), a total of 5 groups. The treatment group were fed different doses of Huoxuetongluo suspension, the model group, the normal group fed distilled water. At 6 weeks and 8 weeks after administration, 8 rabbits in each group were randomly selected for quantitative analysis and detection of plasma VEGF and AKP. Results: At the 6th and 8th week after administration, the void ratio of femoral head was significantly increased (P <0.01) compared with the normal group. Compared with the model group, the emptying rate of the femoral head in Huoxuetongluo Decoction group decreased (P <0.05), but there was significant difference between the high, medium and low dose groups (P <0.05). Conclusion: Huoxue Tongluo Decoction can significantly reduce the void ratio of rabbits with femoral head anomaly, so as to prevent and cure the necrosis of femoral head in rabbits in early and middle period. The curative effect is positively correlated with dose and time.