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目的评价紫杉醇联合铂类药物对晚期非小细胞肺癌的客观疗效及不良反应。方法经病理组织学证实的晚期非小细胞肺癌45例,采用紫杉醇联合铂类药物治疗。结果全组PR 20例,SD 19例,PD 6例,总有效率44.4%。主要不良反应为恶心、呕吐、骨髓抑制、关节肌肉痛等。大部分为Ⅰ~Ⅱ度不良反应,患者耐受良好。结论紫杉醇联合铂类方案是一种对晚期非小细胞肺癌有效的治疗方案,不良反应轻,值得临床进一步研究应用。
Objective To evaluate the objective efficacy and side effects of paclitaxel combined with platinum on advanced non-small cell lung cancer. Methods 45 cases of advanced non-small cell lung cancer confirmed by histopathology were treated with paclitaxel and platinum. Results The whole group PR 20 cases, SD 19 cases, PD 6 cases, the total effective rate 44.4%. The main adverse reactions were nausea, vomiting, myelosuppression, joint muscle pain and so on. Most of Ⅰ ~ Ⅱ degree adverse reactions, patients were well tolerated. Conclusion paclitaxel combined with platinum regimen is an effective treatment for advanced non-small cell lung cancer with mild adverse reactions, it is worth further clinical study.