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目的应用磁共振相位对比法成像(phase contrast magnetic resonance imaging,PC-MRI)测量慢性乙型肝炎患者肝门静脉主干平均血流速度及每分血流量,分析其与肝功能终末期肝病模型(model for end-stage liver dis-ease,MELD)评分的相关性,探讨PC-MRI评价慢性乙型肝炎患者肝功能的应用价值。资料与方法对30名正常自愿者及30例慢性乙型肝炎患者行肝脏PC-MRI,测量并比较正常组与慢性乙型肝炎组间肝门静脉主干平均血流速度及每分血流量,分析慢性乙型肝炎组肝门静脉主干平均血流速度及每分血流量与MELD评分的相关性。结果慢性乙型肝炎组肝门静脉主干平均血流速度及每分血流量较正常组增大,组间差异有统计学意义(P<0.01),慢性乙型肝炎组肝门静脉主干平均血流速度与MELD评分呈显著性负相关,r=-0.61,P<0.01,每分血流量与MELD评分无显著性相关,r=-0.33,P>0.05。结论肝门静脉主干平均血流速度与MELD评分呈显著性负相关,能为慢性乙型肝炎肝功能的评估提供有用的影像学信息。
Objective To measure the mean primary hepatic portal vein blood flow and blood flow per minute in patients with chronic hepatitis B by phase contrast magnetic resonance imaging (PC-MRI), and to analyze its relationship with the model for liver function end-stage liver dis-ease, MELD) score, and to explore the value of PC-MRI in the evaluation of liver function in patients with chronic hepatitis B. Materials and Methods Liver PC-MRI was performed on 30 normal volunteers and 30 chronic hepatitis B patients. The mean primary hepatic portal vein blood flow velocity and blood flow per minute were measured and compared between normal group and chronic hepatitis B group. Chronic Hepatic portal vein hepatic vein mean arterial blood flow velocity and blood flow per minute and the correlation between MELD score of hepatitis B group. Results The mean arterial blood flow velocity and blood flow per minute of hepatic portal vein in chronic hepatitis B group were significantly higher than those in normal group (P <0.01). The mean arterial blood flow velocity in portal vein of chronic hepatitis B group was significantly correlated with MELD score was significantly negatively correlated (r = -0.61, P <0.01). There was no significant correlation between blood flow and MELD score, r = -0.33, P> 0.05. Conclusions The mean primary hepatic portal vein blood flow velocity has a significant negative correlation with MELD score, which can provide useful imaging information for the assessment of liver function in chronic.