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目的在男男性行为人群(MSM)中开展BED-CEIA HIV-1新发感染检测,以估算HIV新发感染率,了解流行趋势。方法对2008-2011年男男性行为人群艾滋病哨点监测中发现的HIV-1感染者进行BED-CEIA检测,估算经灵敏度-特异性校正后该人群的HIV-1年新发感染率,了解其变化趋势。同时设置静脉吸毒人群为对照组,观察该两类人群HIV-1新发感染率水平。结果研究对象共计24 880例。研究组MSM人群3 368例,检出HIV-1阳性300人(含既往阳性26人),完成BED-CEIA检测272人,判为新发感染112人。对照组注射吸毒(IDU)人群21 512例,检出HIV-1阳性3 794例,完成BED-CEIA检测1 791例,判为新发感染190例。2008-2011年MSM人群HIV-1感染率8.91%,低于同期IDU人群的17.6%,而HIV-1新发感染率为7.02%却显著高于同期IDU人群的0.97%。MSM人群2008-2011年HIV-1年新发感染率未出现明显的上升或下降趋势。结论 MSM人群HIV-1新发感染率四年来一直处于较高水平,需重点关注该类人群的艾滋病综合防治。
Objective To develop a new BED-CEIA HIV-1 infection test in men who have sex with men (MSM) to estimate the prevalence of HIV infection and to understand epidemiological trends. Methods BED-CEIA was used to detect HIV-1 infection in sentinel surveillance of HIV-positive men and women in MSM 2008-2011 to estimate the HIV-1 annual new HIV-1 frequency after sensitivity-specificity correction Trend. At the same time, intravenous drug users were set as the control group to observe the new HIV-1 infection rates in the two groups. Results A total of 24 880 subjects were studied. In the study group, 3 368 MSM patients were detected, 300 were HIV-1 positive (including 26 formerly positive), 272 were detected by BED-CEIA, and 112 were newly diagnosed. In the control group, there were 21 512 IDU cases, 3 794 HIV-1 positive cases, 1 791 BED-CEIA cases were detected, and 190 cases were newly diagnosed as IDUs. The HIV-1 infection rate of MSM population was 8.91% in 2008-2011, lower than 17.6% of IDU population in the same period, while the HIV-1 new infection rate was 7.02%, which was significantly higher than 0.97% of IDU population in the same period. MSM population 2008-2011 HIV-1 year, the incidence of newly emerged non-significant increase or decrease. Conclusion The prevalence of HIV-1 infection in MSM population has been at a high level for four years, with a focus on the prevention and treatment of AIDS among these groups.