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人类鼻窦炎窦腔粘膜血流量是否有改变尚无定论。本研究旨在建立慢性鼻窦炎的动物模型以测定窦腔粘膜血流量。作者用家兔作实验,麻醉后按下列三种方法建立实验性鼻窦炎:(1)皮下注射卵清蛋白,每周4次,共2周。窦腔内留置导管注射卵清蛋白,每周3次共2周,并接种肺炎链球菌(10~8个);(2)鼻背部皮肤作切口,鼻窦骨壁钻孔,切开窦腔粘膜放入一块带肺炎球菌的棉绒。(3)与第2种方法相同,但不接种细菌,用异丁稀酸封闭窦口。从实验性鼻窦炎产生到测鼻窦粘膜血流的时间为5周至9个月。部分家兔鼻窦粘膜进行光镜和扫描电镜组织学检查。结果:15只家兔中6只实验失败,其余家兔实验性鼻窦炎的表现是打喷嚏、流涕;鼻窦粘膜
Whether human sinusitis sinus mucosal blood flow changes is not yet conclusive. This study aimed to establish an animal model of chronic sinusitis to measure sinus mucosal blood flow. The authors experiment with rabbits, anesthesia following the establishment of experimental sinusitis by the following three methods: (1) ovalbumin subcutaneous injection 4 times a week for 2 weeks. Overnight catheter catheter ovalbumin, 3 times a week for 2 weeks, and inoculated with S. pneumoniae (10 to 8); (2) nasal dorsal skin incision, sinus osseous wall drilling, incise the sinus mucosa Put in a cotton wool with pneumococcal. (3) The same as the second method, but not inoculated with bacteria, with isobutyl acid to close the ostium. The time from the onset of experimental sinusitis to sinus mucosal blood flow is from 5 weeks to 9 months. Some rabbits sinus mucosa by light microscopy and scanning electron microscopy. RESULTS: Sixteen of fifteen rabbits failed and the performance of the other rabbits with experimental sinusitis was sneezing and runny nose. Sinus mucosa