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美国明尼苏达大学的研究报告指出,122个医疗中心所观察的约13,000名高血压男子的分析表明,接受包括双氢克尿塞在内的强化治疗患者死于心血管病的危险性,应用氯噻酮(研究时所应用的一种利尿剂)的患者为高。 双氢克尿塞所致的死亡率增高,发生于经随机分配接受特殊医疗护理的高血压患者组,而不发生于经随机分配接受常规的或一般的医疗护理的高血压患者组。有些医疗中心以氯噻酮代替
A study by the University of Minnesota pointed out that the analysis of about 13,000 hypertensive men observed in 122 medical centers showed that patients undergoing intensive treatment, including hydrochlorothiazide, were at increased risk of developing cardiovascular disease and chlorthalidone (study time The type of diuretic used) is high in patients. The increased mortality due to hydrochlorothiazide occurred in patients randomized to specific medical care for hypertension but not in those randomized to receive regular or general medical care. Some centers replace chlorthalidone