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目的:研究补阳还五汤合巴曲酶对急性脑梗死患者血浆溶血磷脂酸(LPA)水平的影响。方法:56例急性脑梗死患者随机分为单用组(27例)和联合治疗组(29例),两组均给予巴曲酶治疗;联合组加用补阳还五汤治疗1个疗程。检测两组患者治疗前、治疗后5、7、14和21天的血浆LPA浓度,并与健康体检者(正常对照组)比较。结果 :两组治疗前血浆LPA水平显著高于正常对照组(均P<0.001);治疗后血浆LPA水平逐渐降低,联合组于治疗后14天、单用治疗组于治疗后21天与正常对照组相比差异无显著性(均P>0.05);联合组治疗后5、7、14天血浆LPA水平显著低于单用治疗组(均P<0.001),恢复正常亦早。结论:补阳还五汤合巴曲酶能显著降低急性脑梗死患者的血浆LPA水平,抑制血小板聚集。
Objective: To study the effect of Buyang Huanwu Decoction combined with batroxobin on the level of plasma LPA in patients with acute cerebral infarction. Methods: Fifty-six patients with acute cerebral infarction were randomly divided into single treatment group (n = 27) and combination therapy group (n = 29). Both groups were treated with batroxobin. The combination group was treated with Buyang Huanwu Decoction for one course of treatment. Plasma LPA concentrations were measured before treatment, 5, 7, 14 and 21 days after treatment in both groups, and compared with healthy subjects (normal control group). Results: Plasma LPA levels in both groups before treatment were significantly higher than those in the normal control group (all P <0.001). After treatment, plasma LPA level gradually decreased. In the combination group at 14 days after treatment, (All P> 0.05). The plasma LPA levels in the combined group were significantly lower than those in the monotherapy group on the 5th, 7th and 14th days (all P <0.001), and returned to normal and early. Conclusion: Buyang Huanwu Decoction combined with batroxobin can significantly reduce plasma LPA level and inhibit platelet aggregation in patients with acute cerebral infarction.