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模拟人体胃肠环境,对淀粉微球的降解性能进行了研究,使其在人体中的可控降解成为可能;借助FT-IR对微球降解后的结构进行了表征,粒度分析仪跟踪微球降解过程中的粒度变化;以亚甲基蓝为药物模型,考察了淀粉微球的载药及释药行为。结果表明:可以控制微球在3h内基本不降解,12h内缓慢降解;微球载药率约20%,包封率可达90%;微球在0～2.5h释药迅速,释药量31%,2.5～12h均匀释放,释药量40%,12～24h平衡缓释,释药量10%。
Simulated human gastrointestinal environment, the degradability of starch microspheres was studied to make it possible to control the degradation in human body possible. The structure of the microspheres degraded by FT-IR was characterized by particle size analyzer tracking microspheres Degradation process of particle size changes; Methylene blue as a drug model, investigated the starch microspheres drug loading and drug release behavior. The results showed that the microspheres could be controlled not to degrade within 3 h and slowly degraded within 12 h. The loading rate of microspheres was about 20% and the entrapment efficiency could reach 90%. The microspheres released rapidly from 0 to 2.5 h, 31%, 2.5 ~ 12h uniform release, the release of 40%, 12 ~ 24h balanced sustained release, release of 10%.