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PTEN抑癌基因对肿瘤的发生、发展起到重要作用,与肿瘤的侵袭和预后紧密相关,内源性增殖细胞的标记物增殖细胞核抗原(PCNA)的表达水平与肿瘤增殖有关。本研究采用免疫组织化学技术,探讨抑癌基因PTEN蛋白和PCNA在原发性小肠腺癌中的表达及其与原发性小肠腺癌发生、发展及临床预后性指标的关系,为判断预后提供参考指标。1材料和方法
PTEN tumor suppressor gene plays an important role in tumorigenesis and development, which is closely related to tumor invasion and prognosis. The expression of proliferating cell nuclear antigen (PCNA), a marker of endogenous proliferative cells, is related to tumor proliferation. This study was to investigate the relationship between the expression of tumor suppressor gene PTEN and PCNA in primary small intestinal adenocarcinoma and its relationship with the occurrence, development and clinical prognosis of primary enteric adenocarcinoma by immunohistochemistry. reference indicator. 1 Materials and methods