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头孢匹罗作为第４代头孢菌素，比第３代头孢菌素具有更广的抗菌谱，对肠杆菌科比第３代头孢菌素有更好的抗菌活性，头孢匹罗是已知第３和４代头孢菌素中对革兰阳性细菌抗菌活性最强的抗生素。
Cefpirome, as the fourth generation cephalosporin, has a broader antibacterial spectrum than the third generation cephalosporin and has better antibacterial activity against Enterobacteriaceae than the third generation cephalosporin. Cefpirome is known as the third And fourth-generation cephalosporins Gram-positive bacteria antibacterial activity of the strongest antibiotics.