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乙酰苯胺亚氨二醋酸类衍生物被广泛用作肝胆显像剂,而其前体亚氨二醋酸(IDA)具有经肾脏快速排泄的特性。我们试以放射性核素标记的亚氨二醋酸作肾动态检查,以了解肾脏的功能、形态和尿路通畅情况。IDA分子结构属螯合物,易与核素螯合,因而具有标记简便、标记率高的特点,且易于制备冷冻药盒。药盒每瓶含IDA 3mg,氯化亚锡0.15mg。按常规方法标记,标记率在95％以上。大白鼠静脉注射后30分钟,70％放射性集中于膀胱内。家兔动态显像显示示踪剂在肾脏内通过迅速,经耳静脉注射后1分钟肾影已清晰可见,膀胱内2分钟后即可显现放射性;心前区放射性随示踪剂的清除而迅速下降;泌尿系以外脏器,包
Acetanilimine diacetate derivatives are widely used as hepatobiliary imaging agents and their precursor iminodiacetic acid (IDA) has the property of rapid excretion via the kidneys. We tried radionuclide labeled iminodiacetic acid for renal dynamic examination to understand the kidney function, morphology and urinary tract patency. IDA molecular structure is chelate, easily chelated with radionuclides, which has the characteristics of simple labeling, labeling rate, and easy to prepare frozen kit. Each bottle contains IDA 3mg, stannous chloride 0.15mg. According to the conventional method of labeling, labeling rate of 95% or more. 30 minutes after the intravenous injection of rats, 70% of the radioactivity concentrated in the bladder. Dynamic imaging showed that the tracer in rabbits rapidly through the kidneys, 1 minute after intravenous injection of renal shadow has been clearly visible in the bladder after 2 minutes to show radioactivity; precordial radioactivity with the rapid removal of tracer Declining; urinary organs, packages