论文部分内容阅读
目的探讨2型糖尿病肾病患者(T2DN)血清内脂素水平变化及检测意义。方法选择我院2012年1月-2012年12月收治的47例T2DN患者的临床资料,选择同期我院收治的47例2型糖尿病肾功能正常患者的临床资料作为对照组1,及同期来我院体检的47例健康人作为对照组2,检测三组各生理指标及血清内清脂素水平。结果 SBP、DBP、Hb、FBG、SCr、HDL、LDL、BUN、UA、HbA1c、Cys-c、内脂素等进行比较,观察组SBP高于两对照组,尤其与对照组2比较,结果具有显著性差异(P<0.05);观察组、对照组1患者DBP、FBG、BUN、UA、Cys-c、SCr均高于对照组2,结果具有显著性差异(P<0.05),其中Cys-c、SCr高于对照组1,结果对比具有显著性差异(P<0.05);患观察组者Hb明显低于两对照组,有显著性差异(P<0.05);观察组与对照组1 HbA1c对比具有显著性差异(P<0.05),对照组1与对照组2比较,结果具有显著性差异(P<0.05),观察组与对照组2比较,结果具有显著性差异(P<0.05),但差异性略小于对照组1;三组对比HDL、LDL,结果无显著性差异(P>0.05)。观察组患者与对照组1、2内脂素对比,具有显著性差异(P<0.05)。结论内脂素在T2DN的发生与发展过程中有一定的作用,但其在T2DN发生与发展中的病理生理作用有待进一步研究。
Objective To investigate the changes of serum visfatin levels in patients with type 2 diabetic nephropathy (T2DN) and its significance. Methods The clinical data of 47 T2DM patients admitted from January 2012 to December 2012 in our hospital were selected and the clinical data of 47 patients with type 2 diabetes mellitus with normal renal function treated in our hospital were selected as the control group 1 and 47 cases of physical examination in hospital as control group 2, the detection of three groups of physiological indicators and serum levels of serum lipids. Results SBP, DBP, Hb, FBG, SCr, HDL, LDL, BUN, UA, HbA1c, Cys-c and visfatin in the observation group were higher than those in the two control groups (P <0.05). The DBP, FBG, BUN, UA, Cys-c and SCr in observation group and control group 1 were significantly higher than those in control group 2 (P <0.05) (P <0.05). The Hb in the observation group was significantly lower than that in the two control groups (P <0.05). The levels of 1 HbA1c in the observation group and the control group were significantly higher than those in the control group (P <0.05). There was significant difference between control group 1 and control group 2 (P <0.05), and there was significant difference between observation group and control group 2 (P <0.05) But the difference was slightly less than that of control group 1; There was no significant difference between the three groups in HDL and LDL (P> 0.05). There was significant difference (P <0.05) in the visfatin between observation group and control group. Conclusion The visfatin has a certain role in the occurrence and development of T2DN, but its pathophysiological role in the occurrence and development of T2DN remains to be further studied.