论文部分内容阅读
目的探讨早产儿的细胞免疫功能。方法测定 5 6例早产儿、2 5例足月儿及2 2例正常儿童的血清肿瘤坏死因子α( TNFα)、粒细胞 -巨噬细胞集落刺激因子 ( GM-CSF)、可溶性白细胞介素 2受体 ( s IL- 2 R)水平。结果足月儿组、早产儿 组 (胎龄 >32 w)、早产儿 组 (胎龄 <32 w) TNFα、s IL- 2 R高于对照组 ( P<0 .0 5或 P<0 .0 1 ) ,并且早产儿 、 组、上述指标高于足月儿组 ( P<0 .0 1 ) ;早产儿 、 组、GM- CSF低于对照组和足月儿组 ( P<0 .0 1 ) ,而足月儿组与对照组无明显差异 ( P>0 .0 0 5 )。结论新生儿尤其是早产儿细胞免疫功能尚未发育完善 ,是极其容易发生病毒 ,霉菌和细菌感染的重要原因
Objective To investigate cellular immune function in premature infants. Methods Serum levels of tumor necrosis factor α (TNFα), granulocyte-macrophage colony stimulating factor (GM-CSF), soluble interleukin-2 Receptor (s IL-2 R) levels. Results The levels of TNFα and sIL-2R in term infants, premature infants (gestational age> 32 w) and premature infants (gestational age <32 w) were significantly higher than those in control group (P <0.05 or P <0.05). (P <0.01). Preterm infants, group and GM-CSF were lower than those in control group and full-term infants (P <0. 0 1) 1), while there was no significant difference between term infants and controls (P> 0.05). Conclusion The immune function of newborns, especially premature infants has not yet been well developed, which is an extremely important cause of virus, mold and bacterial infections