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【目的】研究蒲绒栓塞猪肝动脉后猪的病生理学改变。【方法】对蒲绒进行高压蒸汽灭菌处理，作为栓塞剂使用。用9头健康猪作为肝动脉栓塞实验模型，分为三组：蒲绒实验组；明胶海绵组；空白组，比较三组猪的病生理学改变。【结果】病理改变：蒲绒组与明胶海绵组相比，栓塞缺血灶更明显，未出现明显肝纤维化等严重病理异常改变。生理改变：蒲绒组与明胶海绵组在栓塞猪肝动脉后猪血象、凝血、肝功方面相比较无明显差异。【结论】蒲绒具有良好的血管栓塞作用，而且栓塞时间长，栓塞效果稳定，侧支循环建立少而慢，同时具有使用安全和方便，制备简单，材料易得的特点，是一种较理想的末梢型血管栓塞剂。“,”[Objective]To explore the physiological changes in pig liver artery using PuRong embolization .[Methods]We used high pressure steam to sterilize PuRong for embolic reagents .Then ,the embolization was per‐formed in 9 healthy pigs that were divided into a PuRong experimental group ,a Gelatin sponge group ,and the blank group .Physiological and pathological changes were evaluated among three groups .[Results] Pathological changes:Pigs in the PuRong group produce more apparent ischemic areas than pigs in the gelatin sponge group and less signifi‐cant liver fibrosis and other serious pathological changes .Physiological changes:There were no obvious differences be‐tween pigs in the PuRong and gelatin sponge groups in terms of artery blood laboratory examinations ,blood coagula‐tion ,and liver function indicators after embolization .[Conclusion]PuRong is a good vascular embolization with long‐time ,stable ,effective embolism effects .It can establish little and slow collateral circulation .We can easily use it safe‐ly and conveniently .It requires simple preparation ,the characteristics of the materials are accessible ,and it is an ideal type of peripheral vascular embolization agent .