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在左旋多巴治疗帕金森病的初期,衡量帕金森病患者对左旋多巴反应的标准之一是运动功能的持续改善。随着长期使用左旋多巴,绝大多数患者开始出现逐渐加重的运动波动症状,使帕金森病患者的运动障碍在一天之中表现不同。从这种治疗初期疗效的稳定至后来症状的波动,其发生机理尚不清楚。短期反应(SDR)是指帕金森病患者在前一天夜间停用抗帕
In the early stages of levodopa treatment of Parkinson’s disease, one of the criteria for measuring response to levodopa in patients with Parkinson’s disease was a continuous improvement in motor function. With the long-term use of levodopa, the vast majority of patients begin to experience progressive agitation and symptoms of dyskinesia in Parkinson’s disease over the course of a single day. From the initial treatment of such a stable effect to the later symptoms of fluctuations, the mechanism is not yet clear. Short-term response (SDR) refers to patients with Parkinson’s disease the night before the withdrawal of anti-par