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C-反应蛋白(CRP)是一种经典的急性时相蛋白,由Tillett和Francis于1930年首先在急性啼炎患者的血清中发现。因视其能与肺炎双球菌荚膜的C-多糖物质起反应,故名CRP。在正常人体血清中,CRP仅属于一种痕迹量蛋白,99％<10ug/ml。在炎症或急性损伤如急性细菌感染、急性心肌梗塞(AMI)、风湿热或类风湿性关节炎(RA)活动期,进行性和广泛扩散的恶性肿瘤以及手术后等情况下,CRP合成明显增加,且可呈现出与病情演变相平行的临床经过。因此,人们将CRP作为一个反映疾病非特异性变化的客观指标,用于临床诊断、鉴别及监视。近10年
C-reactive protein (CRP) is a classic acute-phase protein, first discovered by Tillett and Francis in the sera of patients with acute inflammatory disease in 1930. Because of its ability to pneumococcal capsule C-polysaccharide material reaction, hence the name CRP. In normal human serum, CRP belongs only to a trace amount of protein, 99% <10 ug / ml. The CRP synthesis is significantly increased in inflammatory or acute injuries such as acute bacterial infections, acute myocardial infarction (AMI), rheumatic fever or rheumatoid arthritis (RA), malignant tumors that progressively and widely spread, and post-operative conditions , And may present a clinical pass parallel to the evolution of the disease. Therefore, people use CRP as an objective indicator of nonspecific changes in the disease for clinical diagnosis, identification and surveillance. Nearly 10 years