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目的 探讨 β干扰素鞘内注射治疗多发性硬化的临床效果及特点。 方法 采用随机对照研究的办法。所有入选病例均符合文献诊断标准 ,用神经功能缺损程度 (NDS)及日常生活活动量 (ADL)作为疗效评判标准。结果 研究组与对照组相比在治疗 1个疗程后、2个疗程后神经功能缺损程度及日常生活活动量评分差异均有显著意义 (P <0 0 1)。结论 β干扰素鞘内注射是治疗多发性硬化的一条有效途径 ,而且比激素治疗更有效。
Objective To investigate the clinical effects and characteristics of intrathecal injection of β interferon in the treatment of multiple sclerosis. Methods Randomized controlled study approach. All selected cases were in line with the diagnostic criteria of the literature, with the degree of neurological deficit (NDS) and the amount of daily living (ADL) as efficacy evaluation criteria. Results Compared with the control group, there was significant difference in the degree of neurological deficits and activities of daily living after one course of treatment between two groups in study group and control group (P <0.01). Conclusion Intrathecal injection of beta interferon is an effective treatment for multiple sclerosis and is more effective than hormone therapy.